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Image Search Results
Journal: Epigenomics
Article Title: LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.
doi: 10.2217/epi-2019-0316
Figure Lengend Snippet: Figure 2. Effect of commonly used drugs in the clinics on HORAS5 expression and selection of cabazitaxel. (A–D) qPCR expression of HORAS5 and reported cMAX and experimental concentrations upon treatment with enzalutamide (LNCAP, (A), carboplatin (DU145-OE, (B) and cabazitaxel (LNCAP) [C]; DU145-OE, [D]) drugs on LNCaP AR+ and DU145 AR- PCa cell lines for 72 h. Results expressed as means ± SD from two independent replicates. One-way ANOVA with Tukey’s post-test was performed for statistical comparison**p = 0.0061, ****p < 0.0001. (E & F) Expression of HORAS5 at different concentrations and different time points of cabazitaxel treatment in LNCAP (E) and DU145-OE (F). Results expressed as means ± SD from two independent replicates. Two-way ANOVA with Sidak’s post-test was performed for statistical comparison ****p < 0.0001. DMSO: Dimethyl sulfoxide; PCa: Prostate cancer; qPCR: Quantitative PCR; SD: Standard deviation.
Article Snippet: 5 mg of enzalutamide (MDV3100,
Techniques: Expressing, Selection, Comparison, Real-time Polymerase Chain Reaction, Standard Deviation